International Journal

The Effects of Exercise Programs on Metabolic and Reproductive Health in Women with PCOS: A Decade in Review (2013–2023)

The Effects of Exercise Programs on Metabolic and Reproductive Health in Women with PCOS: A Decade in Review (2013–2023)

Özge Baykan Çopuroğlu

Journal of Pharmaceutical Research and Innovation . 2025 July; 5(2): 17-23. Published online 2025 July

doi.org/10.36647/JPRI/05.02.A004

Abstract :
Polycystic ovary syndrome (PCOS) is a common endocrine disorder affecting reproductive-aged women, characterized by metabolic dysfunction, hyperandrogenism, and ovulatory disturbances. Exercise has emerged as a key non-pharmacological strategy to manage both metabolic and reproductive complications of the syndrome. This review aims to synthesize evidence from the past decade (2014–2024) on the effects of structured exercise interventions, including aerobic, resistance, and high-intensity interval training (HIIT) on metabolic and reproductive health outcomes in women with PCOS. A narrative review was conducted following PRISMA guidelines. Electronic databases (PubMed, Scopus, and Web of Science) were systematically searched for studies published between January 2014 and December 2024. Eligible studies included randomized controlled trials, cohort studies, and systematic reviews examining the independent effects of exercise on insulin sensitivity, body composition, ovulation, menstrual function, and hormonal profiles in women diagnosed with PCOS. Evidence indicates that structured exercise significantly improves insulin resistance, fasting glucose, lipid profiles, and body composition in women with PCOS. Reproductive benefits include increased menstrual regularity, improved ovulation, and reductions in serum testosterone levels. These effects are observed across different exercise modalities and often occur independently of weight loss. Combined training (aerobic + resistance) appears to provide the most comprehensive benefits. Exercise is a clinically effective and low-risk intervention that should be integrated as a central component of PCOS management, regardless of BMI or phenotype. Personalized exercise prescriptions and long-term adherence strategies are essential to maximize therapeutic outcomes. Future research should focus on standardized protocols and long-term reproductive and metabolic follow-up

Keyword :Exercise Intervention, Insulin Resistance, Metabolic Health, Polycystic Ovary Syndrome, Reproductive Function.