Abstract : Writing research reveals that there is no thorough explanatory approach for the examination of selected pharmaceuticals Nebivolol and Hydrochlorothaizide, ALSK and Amlodipine, and ATNL and BCTM by synchronous estimation using Bio pertinent media in RP-HPLC using Bio pertinent media. HPLC, HPTLC and spectrophotometer are scientific methods that may be used to analyse mixtures either alone or in combination with other procedures. As a result, it was decided that a new logical strategy innovation was required for the simultaneous estimation of Nebivolol and Hydrochlorothaizide, ALSK and Amlodipine, ATNL and BCTM in pharmaceutical dosage frames and their estimate in bioapplicable medium. RP-HPLC for synchronous examination of Nebivolol and Hydrochlorothaizide, ALSK and Amlodipine, and ATNL and BCTM is being developed to establish another fundamental, rapid and accurate, prolific and repeatable RP-HPLC technology. By adhering to ICH regulations, the method will be accepted.

Keyword : — Anti Diabetic, Antihypertensive Drugs, GLC, HPLC, HPTLC, Nebivolol and Hydrochlorothaizide. RP-HPLC