Abstract : The creation and analysis of long-circulatory Nano-liposomes for chemotherapy will be the main topics of this work. By raising the therapeutic index and lowering the toxicity of the medicine, you can increase its effectiveness. The length of blood circulation can be increased by coating the long-circulatory liposome with polyethylene glycol (PEG) and diphenyl phosphate (DPPE) 2000 by acting as a release modifier. The thin film hydration approach was chosen for the PEGylated long-circulatory liposome because this procedure does not result in a heterogeneous population and creates a liposome with a small internal volume. PEG-DPPE was used, and different phospholipid and cholesterol molar ratios were used depending on the temperature at which the phase shift occurred.2000 language used in surface engineering to describe the release modifier. The interaction between PEG-DPPE and drug-sterol2000 Thin film hydration was performed overnight at 500 mmHg and 55 °C on dissolved conjugated polymer dissolved in chloroform to get a pure thin film. A 10% sucrose solution (29.21 m.osmol per liter) was used to hydrate the film. If you want your liposome formulation to be stable and effective, you'll need to make sure that the zeta potential is between 40 and -40 mV, the entrapment efficiency is good, and the particle size is less than 400 nm. The L11 batch was judged to be more optimized than the L10 batch after a comparison of the two. The L11 formulation shows prolonged drug release for up to 13 hours, with an assay of 91.69 percent. Drug entrapment effectiveness is 54.6% and particle size is 298.8 nm in formulation batch L11. Zeta potential is in the range of -22.8 to -29.3 mV. Due to their stability over time and their suitability for bio distribution, long-circulatory liposomes may be used as a drug delivery mechanism at the intended place. All of these considerations led to the conclusion that docetaxel may serve as a model medication. Its water permeability and bioavailability were improved with the use of a liposome formulation.

Keyword : Docetaxel, Thin Film Hydration, Long- Circulatory, Liposome, Extended Release